Description
Protect Your Health with Genetic Testing！PanHERED™ Hereditary Breast and Gynecologic Cancers Panel is designed specifically for women’s health. Whether or not you have a family history of cancer, this test empowers you to understand your genetic risks early, embracing the principle of prevention over cure, and providing peace of mind for you and your family.
Why Is Genetic Testing for Hereditary Breast and Gynecological Cancers Important?
Hereditary cancers are often linked to specific gene mutations that may be passed down through families. Carrying certain high-risk gene mutations significantly increases the likelihood of developing breast or other gynecological cancers. For example:
- BRCA1 mutation: Increases lifetime breast cancer risk to 55–65%.
- BRCA2 mutation: Increases lifetime breast cancer risk to approximately 45–47%.
Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes?
When it comes to the prevention of hereditary breast and ovarian cancer, many people first think of BRCA1 and BRCA2 gene testing. Mutations in these genes significantly increase the lifetime risk of breast cancer (55-65%) and ovarian cancer. However, modern medical research shows that genetic testing extends far beyond BRCA1 and BRCA2. Through multi-gene panel testing, a wider array of relevant genes can be covered, helping to identify a broader spectrum of hereditary risks for more effective early prevention and personalized health management.
While BRCA1 and BRCA2 are major contributors to hereditary breast cancer, they are not the only ones. Research indicates that mutations in other genes can also elevate cancer risk. For instance, mutations in the TP53 gene can lead to a lifetime risk of breast cancer ranging from 46-60%, while mutations in CDH1 can result in a risk of 39-52%. Limiting testing to BRCA1/2 may result in missing 40-50% of hereditary cancer cases.
| Gene | Estimated lifetime risk of breast cancer |
|---|---|
| BRCA1 | 55-65% |
| BRCA2 | 45-47% |
| TP53 | 49-60% |
| PTEN | 25-50% |
| PALB2 | 33-58% |
| STK11 | 30-50% |
| CDH1 | 39-52% |
| ATM | 15-25% |
| CHEK2 | 20-44% |
*The information above is sourced from the Pangenia – PanHERED™ Hereditary Breast and Gynecologic Cancers Panel brochure.
PanHERED™ Hereditary Breast and Gynecologic Cancers Panel
This comprehensive panel covers 20 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, STK11, and TP53) associated with breast, ovarian, and uterine corpus cancers, providing a more comprehensive risk assessment.
Suitable candidates for testing:
- Those with a family history of gynecological cancers such as breast cancer, ovarian cancer, or uterine cancer
- Those diagnosed with breast cancer or gynecological cancer at a young age (under 45 years old)
- Those with both breast cancer and ovarian or uterine cancer
- Those with multiple immediate family members who have had breast cancer, ovarian cancer, or uterine cancer
PanHERED™ is more than just a genetic test—it is a long-term investment in your health and that of your family. By understanding your genetic risks, you can take proactive steps to lower your cancer risk and set a healthy example for future generations. Choose PanHERED™ to start your journey toward health and ensure care for the future.
Sources:
- Hong Kong Cancer Fund, Latest Cancer Statistics
- Hong Kong Medical Journal: A New Paradigm of Genetic Testing for Hereditary Breast/Ovarian Cancers
- The Genetics of Cancer, National Cancer Institute, U.S. Department of Health and Human Services
- Hereditary Cancer, National Taiwan University Hospital, Department of Genomic Medicine
- National Comprehensive Cancer Network
Instructions for use：
- Must be used on or before the expiration date
- Please show your confirmation information, order number, registered full name and phone number for verification
Terms and Conditions：
- This voucher is only valid for Trinity Medical Centre.
- The voucher can be used at Central , Causeway Bay or Tsim Sha Tsui Trinity Medical Centre.
- This voucher must be used within 90 days after purchase and this voucher is not valid after expiration.
- This voucher is non-refundable and cannot be redeemed for full or partial cash.
- You must bring this ticket to the front desk when you register.
- This voucher cannot be used with any other special offers and promotions.
- If this voucher is lost or stolen, we will not accept any liability and will not provide any reissue in such case.
- If you have any questions, please call 2192 7022 or email tmc@trinitymedical.com.hk
- Trinity Medical Centre reserves the right to amend the above Terms and Conditions without prior notice. In case of any disputes, Trinity Medical Centre reserves all rights for the final decision.
